Information for Healthcare Professionals

Medicines and Healthcare products Regulatory Agency

Retail sale of low THC or THC free products have been specifically permitted by the MHRA since 2016, on the basis that no medical claims are made by the manufacturers.

Hemp-derived cannabidiol or CBD has been declared by the World Health Organization’s Expert Committee as safe and well tolerated in humans and animals, with no association for abuse or drug dependence.

Medical claims cannot be made for CBD, however your professional experience is entirely valid and can be communicated to your patients.

CBD oils must not contain more than 1mg per unit (0.2% w/v) THC or they are considered controlled drugs by the Home Office and MHRA.

CBD oil is not Marijuana. Though they come from the same plant species, Cannabis sativa, hemp and CBD products contain less than 0.2% THC, the psychoactive chemical in marijuana. CBD cannot get you high.

Compliance and testing

aróc organics is founded and run by a veterinarian, with consultation from a pharmacist. Compliance is built into our day to day activities. All CBD products are tested twice; by independent Swiss and UK labs to ensure they contain less than 0.2% THC and a certified amount of CBD.

Your patients

Patients may attend your practice looking to use CBD for a number of ailments. This can range from pain management, to anxiety or psoriasis. It should be understood that a pharmaceutical form of CBD called Epididolex has passed extensive safety trials and has demonstrated clinical efficacy in a certain type of childhood epilepsy.

Pharmacokinetics

CBD is not a medicine in the current retail form. However, it has been shown to act on specific receptors (CB1).
CBD is a non-competitive allosteric modulator of CB1 receptors, a biological target currently investigated for CNS and peripheral disease due to anti-inflammatory effects when antagonised.

The main actions of CBD are centrally: 

  • Activates TRPV-1, modulating body temperature, the perception of pain and inflammation.
  • Activates Adenosine receptors, promoting anti-anxiety and dopamine/ glutamate release.
  • Inhibits FAAH enzymes, leading to the modulation of the endogenous CB1 receptor. This seems to help reduce peripheral pain and inflammation.

Rather than the high sensation, CBD actively blocks the neurological effects of THC.

Interactions

Akin to herbal remedies, CBD products have the potential to interact with some medicines. Similar to drug interactions with Grapefruit, high doses of CBD can inhibit cytochrome P450 enzymes. If you have an interaction checking system, adding in an interaction for CBD mirroring Grapefruit is a simple solution.

This information is current as of 2019, the law changes periodically with regard to CBD products and healthcare professionals should ensure they are aware of new guidance.

Last updated May 2019.